Fig 4. Viral enhancement of vomocytosis is not TBK1:IKKε dependent.

Human monocyte-derived macrophages were stimulated with different doses of polyIC (A) or infected with attenuated HIV (B), and subsequently infected with C. neoformans. In B, infection was carried out in the presence or absence of TBK1:IKKε inhibitor (dark gray). Time-lapse microscopy videos were manually scored for vomocytosis. Graphs show Mean + SD of percentage of Cryptococcus-infected macrophages which have experienced at least one vomocytosis event. Chi² test followed by Fisher's exact test performed on raw vomocytosis counts. Pooled data from at least three independent experiments.