Table 1. The calculated pharmacokinetic parameters for N-Acetyl-D-Leucine and N-Acetyl-L-Leucine plasma after oral administration of N-Acetyl-DL-Leucine or N-Acetyl-L-Leucine at a nominal dose of 100 mg/kg.

Compound administered	N-Acetyl-DL-Leucine			N-Acetyl-L-Leucine
Compound quantified	N-Acetyl-D-Leucine		N-Acetyl-L-Leucine	N-Acetyl-D-Leucine	N-Acetyl-L-Leucine
Parameter	Unit	Value	Value	Value	Value
r2	-	0.91	0.93	0.85	0.72
ke	-	2.2	2.8	1.7	2.4
Tmax	h	<0.25	<0.25	<0.25	<0.25
Cmax	ng/mL	86 100	3410	436	16 800
Tlast	h	8.00	2.00	8.00	6.00
Clast	ng/mL	247	623	16.2	168
T1/2	h	0.31	0.4	0.25	0.29
AUC0-last	h x ng/mL	57 800	2 560	573	11 400
Ratio Cmax L/D #	-	0.04		38.5
Ratio AUC L/D #	-	0.04		19.8

^#The ratio of corresponding value between L and D enantiomers