Table 3. Number of days in diarrhea (i.e., fecal score ≥ 3) in the two weeks after infection in piglets.

Salicylatea	SA-		SA+		SEM	P-valuesc
Chestnut extractb	CE-	CE+	CE-	CE+		SA	CE
Days 0‒7d	3.3y	0.7x	3.0y	1.8xy	0.61	0.41	< 0.001
Days 8‒14	0.9	0.1	1.3	0.2	0.35	0.44	< 0.001
Days 0‒14	4.1	0.8	4.3	2.0	0.88	0.35	< 0.001

^x,y Rows carrying no common superscript tended to differ at P < 0.10.

^a SA+: From days 0‒4, pigs (N = 36) were offered a daily dose of sodium salicylate (35 mg/kg BW per day; sodium salicylate, ReagentPlus®, S3007, Sigma-Aldrich Chemie GmbH; Buchs, Switzerland). SA-: From days 0‒4, pigs (N = 36) were offered a daily dose of tap water.

^b CE-: Pigs (N = 36) had ad libitum access to the control standard starter diet, which was formulated according to the Swiss feeding recommendations for pigs (Agroscope, 2017). CE+: Pigs (N = 36) had ad libitum access to the chestnut extract (CE)-supplemented diet, in which wheat straw in the CE- diet was substituted for with 2% CE (Silvafeed Nutri P/ENC for Swine; Italy).

^c P-values for the main effect of salicylate supply (SA), chestnut extract supplementation (CE)

^d Tendency for SA × CE interaction (P = 0.06).