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. 2020 Feb 27;15(2):e0229104. doi: 10.1371/journal.pone.0229104

Fig 6. Gene Ontology and heatmap analysis of transcriptome data.

Fig 6

A. Functional annotation cluster analysis based on Gene Ontology (GO) Biological Process (BP) terms. Analysis was performed using DAVID 6.7 database for differentially expressed genes (FDR < 0.05 and fold change > 2 or < 2) of IR w/ IM vs. K comparison. B. Heatmap generated from triplicate microarray analyses of differentially expressed genes considering a FDR adjusted p-value less than 0.05 as statistically significantly changed. Abbreviations: “K”, K562 cells incubated in complete media; “IR w/o IM”, floating K562-IR cells in suspension incubated in complete media without imatinib for four weeks; “IR w/ IM”, floating K562-IR cells in suspension continuously incubated in complete media with 10μM imatinib; “S”, spindle-shaped K562-IR cells continuously incubated in complete media with 10μM imatinib.