Figure 6.
Cannabis vapor supports conditioned drug seeking in the absence of drug availability or in the presence of drug-related cues. A, Active (colored symbols) and inactive (open symbols) responding for CANTHC, CANCBD, or VEH vapor on the final day of self-administration training (left) and during the first 7 d of extinction training (right). B, Number of trials required to meet extinction criterion (i.e., ≥50% decrease in active nose-poke responses relative to the final self-administration day during the final two extinction sessions). C, Number of nose-poke responses made on the active operanda for CANTHC, CANCBD, or VEH vapor on the final day of extinction (left) and during a cue-induced reinstatement test (left). n = 11–13/group. p ≤ 0.05. ‡Significant difference in responding relative to the final day of (A) self-administration or (C) extinction training. *Significant differences between CANTHC and VEH groups. †Significant differences between CANCBD and VEH groups.