Figure 2.

JMJD6 functions as arginine demethylase (A), lysyl hydroxylase (B) and tyrosine kinase (C). A, Demethylation reactions of symmetric dimethylarginine, monomethylarginine and asymmetric dimethylarginine catalysed by JMJD6. In the first step, JMJD6 hydroxylates the methyl group consuming oxoglutarate (2OG), and in the second step, a deformylation reaction produces formaldehyde (CH2O) to form an unmodified arginine. B, JMJD6 catalyses lysine hydroxylation. C, JMJD6 phosphorylates tyrosine using both guanosine triphosphate (GTP) and adenosine triphosphate (ATP) as phosphate donors