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. 2020 Feb 28;2020(2):CD008959. doi: 10.1002/14651858.CD008959.pub3

ISRCTN57594793.

Methods Design: randomised controlled trial comparing multiple micronutrient powder containing 15 micronutrients vs a micronutrient supplement containing 3 micronutrients
Unit of randomisation: individual randomisation
Participants Setting: Palestine
Sample size: target sample size of 200; unclear how many enrolled
Age range: 5 months + 2 weeks
Inclusion criteria
  1. Aged 5 months + 2 weeks

  2. Normal z scores (> −2 to < 2 standard deviations) of weight‐for‐age, length‐for‐age, and head circumference‐for‐age

  3. Birthweight of 2.5 to 4 kg

  4. Appropriate for gestational age (between 10th and 90th percentiles)

  5. Blood level of haemoglobin of 11 g/dL

  6. Breastfed for at least 4 months

  7. United Nations Relief and Works Agency (UNRWA) clinics for vaccination and/or routine child's growth follow‐up


Exclusion criteria
  1. Preterm infants (< 37 weeks)

  2. History of chronic disease

  3. Infants of diabetic mothers

  4. History of complications during delivery (aspiration, trauma)

  5. History of congenital or acquired neurological diagnosis

Interventions Individuals randomised to 2 groups:
  1. Intervention (100 participants): micronutrient powder with national micronutrient supplement containing 15 vitamins and minerals (unclear dose), produced by DSM (MixMe)

  2. Control (100 participants): national micronutrient supplement containing vitamin A, vitamin D, and iron (unclear dose)


Administration: both groups given 3 sachets/week for 12 months
Outcomes Primary
  1. Anthropometric measurements

  2. Haemoglobin concentration (capillary assessment using colorimeter)


Secondary
  1. Calorie intake, assessed via 24‐hour recall

  2. Nutrient intake, assessed via 24‐hour recall


Timing of outcome assessment: anthropometrics assessed at baseline and throughout the study period (every 3 to 6 months); haemoglobin concentration assessed secondary outcomes assessed at baseline, 6 months of intervention, and end of the intervention period; secondary outcomes assessed at baseline, end‐line, and 3 months after the end of the intervention
Notes Comments: no results published. We contacted study authors but received no reply
Funding source: University Putra Malaysia
Principal investigator: Ali Albelbeisi
Conflicts of interest: none
Trial register ID:ISRCTN57594793
Study start date: 4 September 2015
Study end date: 20 January 2017
Current status: unknown

MNP: multiple micronutrient powder.
 MUAC: mid‐upper arm circumference.
 sTfR: soluble transferrin receptor.
 WLZ: weight‐for‐length z score.