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Foxo3a, But Not Foxo1, Is Downregulated in Uremic Hearts
(A) Representative Western blot for Foxo1 and FoxO3a. (B) Bar graph showing the fold change (n = 6 per group). (C) The expression of FoxO-specific target genes, including Atrogin-1, MuRF-1, Bnip-3, p21, and Pdk4 (n = 6 per group). (D) FoxO3a mRNA levels in uremic hearts and that of the control group (n = 6 per group). #p < 0.05 versus control. FoxO3a,O1 = forkhead transcription factors of the O class.
