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. 2020 Jan 29;5(2):169–179. doi: 10.1016/j.jacbts.2019.11.007

Figure 4.

Figure 4

Inhibition of SGLT2 Reduces Sympathetic Innervation in the Kidney of Hypertensive BPH/2J Mice

Representative immunohistochemistry images of tyrosine hydroxylase expression in kidneys from (A) untreated BPH/2J mice or (B) BPH/2J mice treated with dapagliflozin. Tyrosine hydroxylase staining is indicated with arrows. Magnification 200×. (C) Quantitation of tyrosine hydroxylase expression in kidneys from BPH/2J mice, n = 4 to 6 mice/group. (D) Norepinephrine content in kidneys from BPH/2J mice with or without dapagliflozin treatment, n = 15 to 19 mice/group. (E) Renin concentration in serum from BPH/2J mice with or without dapagliflozin treatment, n = 14 to 18 mice/group. *p = 0.05; **p ≤ 0.01; all data presented as mean ± SEM. Abbreviation as in Figure 1.