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. 2020 Feb 21;11:168. doi: 10.3389/fmicb.2020.00168

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Copyright © 2020 Gunasekera, Muhammad, Strömstedt, Rosengren and Göransson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytotoxicity. Cytotoxicity on a human lymphoma cell line (U-937 GTB). The cell viability derives from the hydrolysis of the probe fluorescein diacetate by esterases in cells with intact plasma membranes. Results are means from triplicates with standard deviation, and the IC50 level is highlighted by a double line. The dose–response curve for LL-37 has been constrained within 100% to compensate for elevated fluorescein hydrolysis by intermediate LL-37 concentrations. The data for KR-12, Q5K,D9K and LL-37 are from our previous work (Gunasekera et al., 2018), but tested in parallel with the dimers and included here for consistency.