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. 2020 Feb 21;10:1662. doi: 10.3389/fphar.2019.01662

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Copyright © 2020 Lopes-Pacheco

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Chemical structure of several CF transmembrane conductance regulator (CFTR) modulators tested in clinical trials or currently in the market. Advances in high-throughput screening technologies have been enabling the identification of small-molecules from different chemical series. In addition to the compounds displayed in this figure, the compounds VX-121, ABBV-2737, ABBV-3067, FDL176, and PTI-808 are also under investigation in clinical trials, but the chemical structures are still not available on the PubChem or DrugBank. *Clinical development has been discontinued.