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. 2020 Feb 21;10:1662. doi: 10.3389/fphar.2019.01662

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Copyright © 2020 Lopes-Pacheco

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Timeline with several milestones in experimental and clinical research for cystic fibrosis since the discovery of CF transmembrane conductance regulator (CFTR) gene in 1989. The knowledge accumulated over these 30 years has been ensuring a better understanding of the molecular biology and protein structure of CFTR, and the pathophysiology of CF in order to translate the basic sciences into clinical practice. More than 10 novel CF therapies have been approved by the U.S. Food and Drug Administration (FDA) during this period with four of these being CFTR modulator drugs.