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. 2020 Feb 21;7:19. doi: 10.3389/fcvm.2020.00019

Table 2.

Mean (SD) heart rate variability values according to sleep stages and sleep cycle.

Cycle onset time Sleep stage and sleep cycle Heart rate variability
Time domain variables Power domain variables
Mean NN SDNN rMSSD LF_FFT HF_FFT LF:HF
21:40 Pre-sleep 704.6 (9.4) 55.9 (3.7) 48.1 (4.6) 1440.8 (388.0) 944.6 (139.6) 1.83 (0.24)
22:58 SWS1 775.7 (10.3) 56.1 (4.1) 68.8 (5.5) 639.4 (94.7) 1768.5 (294.9) 0.68 (0.09)
24:44 SWS2 809.4 (11.5) 57.9 (4.0) 70.8 (5.9) 750.3 (91.5) 1974.8 (346.0) 0.69 (0.07)
01:39 REM3 754.7 (11.1) 62.6 (4.3) 61.8 (5.9) 937.3 (170.8) 1483.1 (364.5) 1.16 (0.12)
02:40 SWS3 824.6 (13.0) 59.7 (4.5) 71.5 (6.7) 922.3 (148.9) 2059.8 (370.1) 1.06 (0.20)
03:26 REM2 772.9 (11.2) 71.6 (5.2) 74.0 (7.3) 1501.2 (243.2) 2299.4 (264.6) 1.82 (0.30)
05:01 REM1 763.7 (10.4) 68.2 (4.3) 67.1 (5.9) 1316.7 (235.4) 2020.5 (377.1) 1.91 (0.26)

Note: Although Stage 3 and 4 are combined for reporting purposes, we restricted our SWS analysis to Stage 4 sleep (Standard Deviation).

SWS, slow wave sleep. SWS cycles are labeled relative to sleep onset: SWS cycle after sleep onset = 1st SWS, SWS cycle after sleep onset but one = 2nd SWS and SWS cycle after sleep onset but two = 3rd SWS cycle. REM, rapid eye movement sleep. REM cycles are labeled relative to sleep offset: REM cycle prior to sleep offset = REM1, REM cycle preceding sleep offset but one = REM2 and REM cycle preceding sleep offset but two = REM3 (see Figure 1).