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. 2020 Jan 25;225(2):639–667. doi: 10.1007/s00429-020-02026-5

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© The Author(s) 2020

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Fig. 19 — Metabolic considerations of a neuronal mitochondrion (blue box) and a glial mitochondrion (orange box) pertinent to KGDHC. AC aconitase, BDH β-hydroxybutyrate dehydrogenase, CS citrate synthase, FH fumarase, GAD glutamate decarboxylase, GABA-T GABA aminotransferase, GDH glutamate dehydrogenase, GLSc glutaminase (cytosolic), GLSm glutaminase (mitochondrial), GOT2 aspartate aminotransferase, IDH isocitrate dehydrogenase, KGDHC ketoglutarate dehydrogenase complex, MDH malate dehydrogenase (mitochondrial), OXCT1 succinyl-CoA:3-oxoacid CoA-transferase, PC pyruvate carboxylase, PDHC pyruvate dehydrogenase complex, SDH succinate dehydrogenase, SSADH succinic semialdehyde dehydrogenase, SUCL succinyl-CoA ligase