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. 2020 Feb 27;10:3652. doi: 10.1038/s41598-020-60707-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evidence of immune checkpoint molecules and immune scores in Mes compared with Epi subgroups of HNSCC. (A) PD-1 and PD-L1 levels were significantly elevated in Mes subgroup as compared with Epi subgroup in the TCGA and Leipzig cohorts. (B) CTLA-4 level was significantly higher in the Mes subgroup than that in the Epi subgroup in the TCGA and Leipzig cohorts. (C) The INFG and CYT scores were analyzed in the Mes subgroup in comparison with the Epi subgroup of HNSCC patients for gene expression data from the TCGA and Leipzig cohorts. (D) TIS and IIS were analyzed in the Mes subgroup in comparison with the Epi subgroup of HNSCC patients for gene expression data from the TCGA cohort. (E) The IS score was significantly elevated in Mes subgroup as compared with Epi subgroup in the TCGA and Leipzig cohorts.