Table 4.
Estimated fixed effects for cognitive decline in FCSRT-IR and MOCA in the aMCI group and influence of age, gender and APOE e4-status.
| Model 1 | Model 2 | |||||
|---|---|---|---|---|---|---|
| B | 95% CI | P | B | 95% CI | P | |
| FCSRT-IR | ||||||
| Intercept | 38.13 | 36.30,39.96 | <0.001 | 42.86 | 40.09,45.64 | <0.001 |
| Time (years) | −2.73 | −3.70,−1.77 | <0.001 | −1.05 | −2.50,0.40 | 0.15 |
| Age at baseline | −0.14 | −0.36,0.09 | 0.23 | |||
| Gender (female) | −5.94 | −9.50,−2.38 | 0.001 | |||
| Gender x time | −1.25 | −3.25,0.76 | 0.22 | |||
| APOE-e4 (present) | −4.58 | −8.08,−1.08 | 0.010 | |||
| APOE-e4 x time | −2.65 | −4.57,−0.74 | 0.006 | |||
| MOCA | ||||||
| Intercept | 22.79 | 22.35,23.23 | <0.001 | 23.80 | 23.13,24.47 | <0.001 |
| Time (years) | −1.14 | −1.56,−0.72 | <0.001 | −0.55 | −1.18,0.08 | 0.086 |
| Age at baseline | −0.08 | −0.13,−0.03 | 0.003 | |||
| Gender (female) | −1.76 | −2.62,−0.90 | <0.001 | |||
| Gender x time | −0.38 | −1.24,0.49 | 0.39 | |||
| APOE-e4 (present) | −0.34 | −1.18,0.51 | 0.44 | |||
| APOE-e4 x time | −0.81 | −1.64,0.02 | 0.054 | |||
MOCA = Montreal Cognitive Assessment; FCSRT-IR = Free and Cued Selective Reminding Test with immediate recall; ApoE ε4 = Apolipoprotein E ε4 allele carrier.