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. 2020 Feb 27;10:3576. doi: 10.1038/s41598-020-60271-4

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© The Author(s) 2020, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HDAC6 is upregulated in EC tissues and cell lines. (A) According to the Human Protein Atlas (https://www.proteinatlas.org), Kaplan-Meier survival curves indicated that high HDAC6 expression was correlated with poorer survival probability. (B) HDAC6 expression in different EC stages according to UALCAN (http://ualcan.path.uab.edu/index.html). (C) qRT-PCR showed higher HDAC6 expression in EC tissues than in paired adjacent normal tissues (n = 46). (D) Western blot analysis showed that cancer tissues expressed more HDAC6 than paracancerous control tissues (n = 46). (E) IHC analysis showed the HDAC6 expression levels in paraffin-embedded normal endometrial and EC specimens (100×, 200×). (F) Western blot analysis showed the HDAC6 expression levels in four selected EC cell lines—HEC-1-A, Ishikawa, AN3C, and RL95—and in one immortalized endometrial fibroblast cell line. (G) qRT-PCR showed HDAC6 mRNA levels in the EC cell lines and immortalized endometrial fibroblast cell line. **P < 0.01, ***P < 0.001, ****P < 0.0001.