Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 27;10:3576. doi: 10.1038/s41598-020-60271-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

HDAC6 is a direct target gene of miR-206. (A) The TargetScan (http://www.targetscan.org/) prediction algorithm identified miR-206 as a potential miRNA targeting the 3′-UTR of HDAC6 mRNA. (B) A dual luciferase assay was conducted to verify the prediction. (C) The relationship between miR-206 and HDAC6 in EC tissues was shown by Pearson correlation analysis (n = 46). (D) Western blotting showed HDAC6 protein levels in Ishikawa cells after transfection with the miR-206 inhibitor and miR-206 mimic. (E) Heat map showing the dysregulated genes after miR-206 overexpression and knockdown in AN3C cells. (F) KEGG pathway analysis of the top 25 differentially expressed genes. *P < 0.05, ***P < 0.001.