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. 2020 Feb 27;10:3629. doi: 10.1038/s41598-020-60594-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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STZ-induced type 1 diabetes mellitus is associated with impaired morphological parameters. (a) Blood glucose levels (mg/dl) in control mice and 6w, 9w, and 12w after STZ application. Besides increased blood glucose, mice suffering from type 1 diabetes displayed lower body weight (g) over time (b). As morphological parameters, LV mass (mg; c) and LV mass/body weight (d) are depicted. Bar graphs represent the mean ± SEM. Data were analysed with One-way ANOVA or Kruskal-Wallis test (*p < 0.05; **p < 0.01, ***p < 0.001, ***p < 0.0001 versus corresponding control; ^†p < 0.05, ^††p < 0.01, ^†††p < 0.001, ^††††p < 0.0001 versus the 6w STZ; ^‡p < 0.05, ^‡‡p < 0.01, ^‡‡‡p < 0.001, ^‡‡‡‡p < 0.0001 versus the 9w STZ; n = 12/controls and n = 14/STZ).