Figure 3.

Loss of AIF1L does not affect total weight gain or body composition during short term HFD feeding. (n = 3 for WT and n = 4 for KO). (a) Weight gain over 6 weeks of HFD feeding (Flattening of the curves at week 6 in these mouse cohorts followed a move to the Animal Physiology core facility for subsequent metabolic cage and MRI studies; other cohorts (e.g., Fig. 4a, Supplementary Fig. 5a) used in weight gain or glucose sensitivity studies did not show similar flattening of the weight curve.). (b) Food intake over 5 weeks of HFD feeding (n = 3 for WT and n = 4 for KO). (c) Body weight, fat, and lean mass measurements determined by MRI. (d) Brown (BAT), inguinal subcutaneous (iSAT), epididymal (eWAT) white adipose depot, and liver mass. (e) Macroscopic appearance of tissues - representative images. Data are represented as mean ± SEM. ns – not significant.