Table 1.
Comparison of epidemiological characteristics between endometrial carcinoma patients with or without leiomyomas, adenomyosis or endometriosis.
| Characteristic | EC patients without Leiomyomas (n = 582) | EC patients with Leiomyomas (n = 817) | bP | EC patients without adenomyosis (n = 827) | EC patients with adenomyosis (n = 572) | bP | EC Patients without endometriosis (n = 1220) | EC patients with endometriosis (n = 179) | bP |
|---|---|---|---|---|---|---|---|---|---|
| aN (%) | aN (%) | aN (%) | aN. (%) | aN (%) | aN (%) | ||||
| Mean age at EC diagnosis (range) | 60.7 (26.4–80.0) | 61.6 (28.9–80.0) | 0.02 | 61.6 (26.4–80.0) | 60.8 (31.9–80.0) | 0.2 | 61.9 (26.4–80.0) | 57.0 (28.9–78.9) | 5.0 × 10−11 |
| Body Mass Index | |||||||||
| <25 | 138 (23.8) | 209 (25.6) | 211 (25.7) | 136 (23.8) | 292 (24.1) | 55 (30.7) | |||
| 25–29.9 | 153 (26.4) | 202 (24.8) | 225 (27.4) | 130 (22.8) | 311 (25.6) | 44 (24.6) | |||
| ≥30 | 289 (49.8) | 401 (49.2) | 0.6 | 385 (46.9) | 305 (53.4) | 0.05 | 610 (50.3) | 80 (44.7) | 0.03 |
| Oral Contraceptive use | |||||||||
| never | 198 (34.0) | 258 (31.6) | 307 (37.1) | 149 (26.1) | 402 (33.0) | 54 (30.2) | |||
| ever | 384 (66.0) | 558 (68.4) | 0.4 | 520 (62.9) | 422 (73.9) | 6.6 × 10−5 | 817 (67.0) | 125 (69.8) | 0.3 |
| Parity | |||||||||
| 0 | 89 (15.3) | 158 (19.3) | 182 (22.0) | 65 (11.4) | 205 (16.8) | 42 (23.5) | |||
| 1 | 64 (11.0) | 76 (9.3) | 86 (10.4) | 54 (9.4) | 112 (9.2) | 28 (15.6) | |||
| ≥2 | 429 (73.7) | 583 (71.4) | 0.01 | 559 (67.6) | 453 (79.2) | 1.9 × 10−9 | 903 (74.0) | 109 (60.9) | 0.07 |
| Age at Menarche | |||||||||
| ≤11 | 108 (18.8) | 206 (25.4) | 180 (21.9) | 134 (23.7) | 272 (22.5) | 42 (23.5) | |||
| 12–13 | 284 (49.4) | 382 (47.1) | 398 (48.5) | 268 (47.4) | 577 (47.8) | 89 (49.7) | |||
| ≥14 | 183 (31.8) | 223 (27.5) | 0.004 | 243 (29.6) | 163 (28.8) | 0.9 | 358 (29.7) | 48 (26.8) | 1 |
| Smoking | |||||||||
| never | 369 (63.5) | 539 (66.0) | 523 (63.3) | 385 (67.3) | 792 (65.0) | 116 (64.8) | |||
| ever | 212 (36.5) | 278 (34.0) | 0.6 | 303 (36.7) | 187 (32.7) | 0.1 | 427 (35.0) | 63 (35.2) | 0.7 |
| cFamily History any cancer (FDR &/or SDR) | |||||||||
| no | 213 (36.6) | 285 (34.9) | 295 (35.7) | 203 (35.5) | 445 (36.5) | 53 (29.6) | |||
| yes | 369 (63.4) | 532 (65.1) | 0.6 | 532 (64.3) | 369 (64.5) | 0.9 | 775 (63.5) | 126 (70.4) | 0.06 |
EC, endometrial carcinoma; FDR, first-degree relative, SDR, second-degree relative.
aNs may not sum to the total because of missing or unknown data; proportions (%) sum to 100% of observations with data available and excludes missing/unknowns.
bP-values are from logistic models comparing presence of a condition versus not; models are adjusted for age at EC diagnosis and presence of the other two gynecologic conditions; p-values for BMI, Parity and age at menarche represent trend across ordered groups.
cFamily history of cancer reported in at least one FDR or SDR.