Table 4.
Overall and EC-specific survival in patients according to gynecologic conditions.
| EC Patient subgroup | N Died (%) | EC-specific Survival | Overall Survival | ||
|---|---|---|---|---|---|
| aHR (95% CI) | P | aHR (95% CI) | P | ||
| bIndividual conditions | |||||
| Leiomyomas (n = 817) | 94 (11.5) | 0.67 (0.47–0.96) | 0.027 | 0.68 (0.51–0.91) | 0.011 |
| Adenomyosis (n = 572) | 56 (9.8) | 0.67 (0.44–1.04) | 0.074 | 0.88 (0.63–1.21) | 0.431 |
| Endometriosis (n = 179) | 23 (12.8) | 0.74 (0.39–1.40) | 0.354 | 1.19 (0.75–1.88) | 0.458 |
| Coexisting conditions | |||||
| None (n = 352) | 71(20.2) | 1.00 | 1.00 | ||
| Leiomyomas only (n = 385) | 50 (13.0) | 0.58 (0.37–0.89) | 0.012 | 0.57 (0.39–0.83) | 0.003 |
| Adenomyosis only (n = 174) | 20 (11.5) | 0.52 (0.25–1.07) | 0.076 | 0.77 (0.46–1.28) | 0.3 |
| Endometriosis only (n = 37) | 4 (10.8) | 0.47 (0.14–1.54) | 0.21 | 0.56 (0.20–1.55) | 0.3 |
| Leiomyomas & Adenomyosis (n = 309) | 27 (8.7) | 0.55 (0.31–0.98) | 0.043 | 0.60 (0.38–0.95) | 0.03 |
| Leiomyomas & Endometriosis (n = 53) | 10 (18.9) | 0.79 (0.31–2.00) | 0.616 | 1.21 (0.62–2.38) | 0.6 |
| Adenomyosis & Endometriosis (n = 19) | 2 (10.5) | 1.03 (0.14–7.54) | 0.978 | 1.28 (0.31–5.27) | 0.7 |
| All three conditions (n = 70) | 7 (10.0) | 0.25 (0.06–1.08) | 0.064 | 0.74 (0.33–1.66) | 0.5 |
| Prior/Concurrent Ovarian Cancer | |||||
| No ovarian cancer (n = 1369) | 184 (13.4) | 1.00 | 1.00 | ||
| Prior/Concurrent ovarian cancer (n = 30) | 7 (23.3) | 0.55 (0.16–1.90) | 0.343 | 1.18 (0.52–2.68) | 0.7 |
EC, endometrial carcinoma; HR, Hazard Ratio; CI, confidence Interval; LVSI, lymphovascular space involvement.
aEstimates are based on Cox modelling of factor variables using left-truncation; covariates includes age at EC diagnosis (continuous), FIGO stage I, II, III + IV (factor variables); histology endometrioid Grade 1, endometrioid Grade 2, endometrioid Grade 3, serous, clear cell, MMMT, other epithelial (factor variables) and LVSI no/unknown, yes.
bAnalysis of EC patients with specified condition vs not, irrespective of presence of another condition.