Table 2.

Multivariate analysis to identify factors predicting inferior outcomes.

	EFS				OS
	HR	95% CI		p	HR	95% CI		p
NCI-HR vs. SR	1.37	1	1.89	0.05	1.53	1.03	2.27	0.03
JACLS risk	1.46	1.1	2	0.02	1.88	1.28	2.77	0.001
ETV6-RUNX1+HHD (absent vs. present)	1.53	1.07	2.2	0.02	1.79	1.11	2.91	0.02
Hypodiploid+other abnormalitiesa (absent vs. present)	0.6	0.44	0.92	0.01	0.59	0.38	0.91	0.02
PPR vs. PGR	1.38	0.84	2.27	0.21	0.93	0.51	1.7	0.82

EFS event-free survival, OS overall survival, HR hazard ratio, CI confidence interval, NCI National Cancer Institute, HR high risk, SR standard risk, PGR prednisolone good response, PPR prednisolone poor response.

^aCytogenetic/genetic abnormalities other than ETV6-RUNX1, TCF3-PBX1, high hyperdiploid, 11q23 rearrangement/KMT2A-related fusion, normal karyotype, and karyotypic failure.