Table 2.
Multilevel mixed-effects regression analysis evaluating the effect of the peri-implantitis model on the regenerative outcome of BMP2 gene therapy. A mixed-effects regression analysis was performed, and the significance level was set at p 0.05. Adjusted model 1: random-effects – dog. Adjusted model 2: fixed-effects – defect depth, dog *Bone graft area directly contacting the bone.
| Crude model | p-value | Adjusted model 1 | p-value | Adjusted model 2 | p-value | |
|---|---|---|---|---|---|---|
| Coefficient (CI) | Coefficient (CI) | Coefficient (CI) | ||||
| Buccal side | ||||||
| Newly formed bone area (mm2) | 0.11 (0.03–0.19) | 0.010 | 0.11 (0.04–0.18) | 0.001 | 0.08 (–0.01–0.17) | 0.079 |
| Area of the bone graft (mm2) | 0.15 (–0.02–0.32) | 0.081 | 0.15 (0.00–0.30) | 0.044 | 0.07 (–0.09–0.23) | 0.397 |
| Total mineralized tissue area (mm2) | 0.07 (0.02–0.13) | 0.016 | 0.07 (0.02–0.12) | 0.003 | 0.05 (–0.01–0.11) | 0.129 |
| Re-osseointegration height (mm) | 0.41 (0.04–0.78) | 0.031 | 0.41 (0.10–0.73) | 0.011 | 0.26 (–0.08–0.60) | 0.140 |
| Vertical bone fill (percentage) | 1.13 (0.24–2.01) | 0.016 | 1.13 (0.37–1.88) | 0.003 | 0.75 (–0.60–2.10) | 0.278 |
| Lingual side | ||||||
| Newly formed bone area (mm2) | 0.14 (–0.02–0.30) | 0.080 | 0.14 (0.00–0.28) | 0.044 | 0.1 (–0.03–0.22) | 0.127 |
| Area of the bone graft (mm2) | 0.48 (0.08–0.87) | 0.021 | 0.48 (0.14–0.82) | 0.005 | 0.36 (0.03–0.69) | 0.033 |
| Total mineralized tissue area (mm2) | 0.12 (0.01–0.24) | 0.042 | 0.12 (0.02–0.23) | 0.017 | 0.09 (–0.01–0.19) | 0.069 |
| Re-osseointegration height (mm) | 0.30 (0.00–0.60) | 0.050 | 0.30 (0.04–0.56) | 0.022 | 0.23 (0.00–0.47) | 0.050 |
| Vertical bone fill (percentage) | 1.00 (0.18–1.82) | 0.021 | 1.00 (0.29–1.70) | 0.005 | 0.69 (–0.08–1.47) | 0.080 |