Table 1.
Demographics Of The Study Participants.
| HCs (n = 51) | MS patients (n = 122) | RRMS (n = 58) | PPMS (n = 28) | SPMS (n = 36) | *P values | |
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Age, years | 41 ± 13 | 48 ± 11 | 42 ± 10 | 52 ± 9 | 53 ± 7 | p < 0.001a |
| Gender (M/F) | 25/26 | 36/86 | 18/40 | 10/18 | 8/28 | p = 0.06b |
| Disease duration, years | — | 15 ± 10 | 11 ± 8 | 14 ± 7 | 22 ± 10 | p < 0.001a |
| % (no) patients of DMTs | — | 58 (67) | 84 (48) | 13 (3) | 47(16) | p < 0.001b |
| LL (ml) | — | 14.37 ± 15.92 | 12.78 ± 15.72 | 16.56 ± 19.83 | 15.23 ± 12.73 | p < 0.001a |
| Clinical scores | ||||||
| EDSS, median | — | 5.5 (0–8.5) | 2 (0–7) | 6 (3–8) | 6.5 (4–8.5) | p < 0.001a |
| SDMT | 65.08 ± 8.31 | 45.50 ± 13.27 | 51.04 ± 14.28 | 42.86 ± 9.46 | 39.00 ± 10.88 | p < 0.001a |
Abbreviations: HCs = Healthy controls; MS = multiple sclerosis; RRMS = relapsing remitting MS; PPMS = primary progressive MS; SPMS = secondary progressive MS; DMT = Disease Modifying Treatment; LL = Lesion load; EDSS = Expanded Disability Status Scale; SDMT = Symbol Digit Modalities Test; ANOVA = analysis of variance.
*P values in bold denote statistical significance at p < 0.05; statistical test between the various clinical subtypes and healthy controls where applicable.
aOne-way ANOVA.
bChi Squared test.