Table 2.

Network Hubs In Healthy Controls And Multiple Sclerosis Subtypes.

Brain region	HCs (x105)	RRMS (x105)	PPMS (x105)	SPMS (x105)
Frontal lobe
Right precentral gyrus	3.39 (0.21)	3.34 (0.27)	3.27 (0.24)	3.23 (0.23)
Left precentral gyrus	3.53 (0.23)	3.38 (0.28)	3.36 (0.30)	3.34 (0.32)
Right superior frontal gyrus	3.37 (0.18)	3.22 (0.23)	3.11 (0.26)	3.09 (0.25)
Left superior frontal gyrus	3.28 (0.17)	3.20 (0.26)	3.10 (0.03)	3.13 (0.24)
Right middle frontal gyrus	2.88 (0.20)	2.78 (0.25)	2.75 (0.23)	2.58 (0.22)
Left middle frontal gyrus	3.04 (0.19)	2.92 (0.27)	2.77 (0.23)	2.76 (0.22)
Parietal lobe
Right postcentral gyrus	2.25 (0.10)	2.28 (0.16)	2.20 (0.16)	2.16 (0.18)
Left postcentral gyrus	2.32 (0.12)	2.27 (0.14)	2.31 (0.19)	2.32 (0.18)
Right superior parietal lobule	2.26 (0.10)	2.21 (0.13)	2.09 (0.16)	2.08 (0.15)
Left superior parietal lobule	2.01 (0.10)	1.96 (0.12)	1.93 (0.13)	1.85 (0.11)
Right precuneus	2.20 (0.10)	2.14 (0.13)	2.10 (0.16)	1.98 (0.13)
Left precuneus	2.01 (0.10)	1.95 (0.12)	1.94 (0.13)	1.85 (0.12)
Temporal lobe
Right middle temporal gyrus	2.06 (0.10)	1.96 (0.13)	1.89 (0.12)	1.88 (0.12)
Left middle temporal gyrus	1.85 (0.09)	1.78 (0.12)	1.73 (0.10)	1.74 (0.11)
Subcortical grey matter
Right thalamus	2.67 (0.15)	2.32 (0.02)	2.27 (0.19)	2.08 (0.15)
Left thalamus	2.53 (0.15)	2.22 (0.13)	2.23 (0.17)	2.06 (0.14)
Right putamen	2.34 (0.13)	2.13 (0.12)	2.11 (0.02)	2.03 (0.13)
Left putamen	2.20 (0.09)	2.03 (0.11)	2.04 (0.15)	1.94 (0.13)

Average values and standard deviations (SD) of region-specific strength.

Bold values represent regions that exhibit significant decrease in nodal strength against HCs. The italicized regions are those that belong to the first principal network in healthy controls.

Abbreviations: HCs = healthy controls; RRMS = relapsing-remitting MS; PPMS = primary progressive MS; SPMS = secondary progressive MS.

Reproduced from Charalambous⁴⁴.