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. 2020 Feb 27;10:3637. doi: 10.1038/s41598-020-59660-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of the protein-coding transcriptome in cSCC. (A) Principal component analysis of samples obtained frmo healthy skin samples (H; blue) and cSCC (cSCC; yellow) based on RNA-seq data. (B) Volcano plot shows the result of EdgeR-analysis of all detected mRNAs (log₂ fold change versus log₁₀ nominal P-value for all detected genes). Vertical lines denote the fold change cutoff, while the horizontal line denotes the P-value cutoff. Red color represents upregulated and blue color represents downregulated coding transcripts. (C) Heatmap and hierarchical clustering of all differentially expressed protein-coding genes in cSCC (FDR < 0.05 and FCH > 1.5).