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. 2020 Feb 27;10:3637. doi: 10.1038/s41598-020-59660-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Detection of abundant circRNAs in healthy skin and cSCC. Pie charts showing the distribution of the numbers of exons annotated within the back-splicing junction of the high abundance circRNAs in healthy skin (A) and in cSCC (B). (C) Venn-diagram showing the overlap between the high abundance circRNAs detected in the normal skin biopsies (left) and the cSCC biopsies (right). (D) Column scatter plot showing the average RPM for the 264 unique high abundance circRNAs detected in the normal skin- and cSCC biopsies combined. Mann-Whitney U test.