Table 2.

Pre-erythrocytic antigens used in vaccines.

Antigen					Vaccine		References
Name	Symbol	Size (aa)	Accession*	Expression	Name	Phase
Circumsporozoite protein	CSP	397	PF3D7_0304600	Sporozoite and liver-stage	RTS,S/ASO1	Phase III	(3, 54)
Thrombospondin-related anonymous protein	TRAP	574	PF3D7_1335900	Liver-stage and gametocytes	ChAd63	Phase IIb	(30, 54, 55)
Liver stage antigen 1	LSA1	1,162	PF3D7_1036400	Liver-stage	ChAd63 and MVA	Pre-clinical	(29, 51, 54, 56)
Liver stage antigen 3	LSA3	1,558	PF3D7_0220000	Liver-stage and blood stage	ChAd63 and MVA	Pre-clinical	(51)
Liver stage associated protein 1	LSAP1	106	PF3D7_1201300	Sporozoite and liver-stage	ChAd63 and MVA	Pre-clinical	(51)
Liver stage associated protein 2	LSAP2	302	PF3D7_0202100	Sporozoites, liver-stage and early ring stage	ChAd63 and MVA	Pre-clinical	(51)
Early transcribed membrane protein 5	ETRAMP5	181	PF3D7_0532100	Sporozoite, liver-stage, blood-stage	ChAd63 and MVA	Pre-clinical	(51)
Cell traversal protein for ookinetes and sporozoites	CelTOS	182	PF3D7_1216600	Sporozoite, liver-stage and gametocytes	ChAd63 and MVA	Pre-clinical	(51, 57)
Protein UIS3	UIS3	229	PF3D7_1302200	Sporozoite, liver-stage and blood-stage	ChAd63 and MVA	Pre-clinical	(51)
Falstatin	Falstatin	413	PF3D7_0911900	Sporozoite, liver-stage and blood-stage	ChAd63 and MVA	Pre-clinical	(51)
Liver specific protein 1	LISP1	3,597	PF3D7_1418100	Liver stage	DNA	Pre-clinical	(43, 44)
Sporozoite and liver stage asparagine-rich protein	SLARP	2,940	PF3D7_1147000	Liver stage	DNA	Pre-clinical	(43, 44)

^*P. falciparum clone 3D7 accession numbers obtained from PlasmoDB Release 38 (58).