Table 2.
Gene Ontology analysis of differentially expressed genes associated with colorectal cancer.
| Expression | Category | Term | Count | % | P value | FRD |
|---|---|---|---|---|---|---|
| Upregulated | GOTERM_BP_DIRECT | GO:0030574~collagen catabolic process | 19 | 3.38 | 6.88E-16 | 1.14E-12 |
| GOTERM_BP_DIRECT | GO:0030198~extracellular matrix organization | 25 | 4.45 | 4.39E-12 | 7.53E-09 | |
| GOTERM_BP_DIRECT | GO:0030199~collagen fibril organization | 13 | 2.31 | 1.60E-11 | 2.75E-08 | |
| GOTERM_BP_DIRECT | GO:0051301~cell division | 26 | 4.63 | 1.28E-07 | 2.19E-04 | |
| GOTERM_BP_DIRECT | GO:0000082~G1/S transition of mitotic cell cycle | 14 | 2.49 | 2.40E-07 | 4.11E-04 | |
| GOTERM_CC_DIRECT | GO:0005201~extracellular matrix structural constituent | 12 | 2.14 | 1.18E-07 | 1.73E-04 | |
| GOTERM_CC_DIRECT | GO:0050840~extracellular matrix binding | 8 | 1.42 | 7.27E-07 | 1.06E-03 | |
| GOTERM_CC_DIRECT | GO:0048407~platelet-derived growth factor binding | 6 | 1.07 | 1.55E-06 | 2.26 E-03 | |
| GOTERM_CC_DIRECT | GO:0008009~chemokine activity | 9 | 1.60 | 6.77E-06 | 9.87 E-03 | |
| GOTERM_CC_DIRECT | GO:0005509~calcium ion binding | 31 | 5.52 | 2.18E-04 | 0.32 | |
| GOTERM_MF_DIRECT | GO:0005578~proteinaceous extracellular matrix | 28 | 4.98 | 4.16E-12 | 5.63E-09 | |
| GOTERM_MF_DIRECT | GO:0005576~extracellular region | 71 | 12.63 | 2.09E-10 | 2.83E-07 | |
| GOTERM_MF_DIRECT | GO:0005615~extracellular space | 61 | 10.85 | 2.12E-09 | 2.87E-06 | |
| GOTERM_MF_DIRECT | GO:0005581~collagen trimer | 14 | 2.49 | 3.07E-08 | 4.16E-05 | |
| GOTERM_MF_DIRECT | GO:0031012~extracellular matrix | 22 | 3.91 | 4.80E-07 | 6.49E-04 | |
| Downregulated | GOTERM_BP_DIRECT | GO:0015701~bicarbonate transport | 8 | 2.60 | 1.19E-06 | 1.91 E-03 |
| GOTERM_BP_DIRECT | GO:0006936~muscle contraction | 10 | 3.25 | 8.46E-06 | 0.01 | |
| GOTERM_BP_DIRECT | GO:0051453~regulation of intracellular pH | 6 | 1.95 | 8.39E-05 | 0.13 | |
| GOTERM_BP_DIRECT | GO:1902476~chloride transmembrane transport | 8 | 2.60 | 1.75E-04 | 0.28 | |
| GOTERM_BP_DIRECT | GO:0006730~one-carbon metabolic process | 5 | 1.63 | 5.23E-04 | 0.83 | |
| GOTERM_CC_DIRECT | GO:0005254~chloride channel activity | 6 | 1.95 | 4.91E-04 | 6.73 | |
| GOTERM_CC_DIRECT | GO:0004089~carbonate dehydratase activity | 4 | 1.30 | 5.82E-04 | 7.98 | |
| GOTERM_CC_DIRECT | GO:0051287~NAD binding | 5 | 1.63 | 1.13 E-03 | 1.54 | |
| GOTERM_CC_DIRECT | GO:0005179~hormone activity | 6 | 1.95 | 5.77 E-03 | 7.65 | |
| GOTERM_CC_DIRECT | GO:0005229~intracellular calcium activated chloride channel activity | 3 | 9.75 | 0.02 | 19.61 | |
| GOTERM_MF_DIRECT | GO:0070062~extracellular exosome | 69 | 2.24 | 1.68E-08 | 2.13E-05 | |
| GOTERM_MF_DIRECT | GO:0005615~extracellular space | 38 | 12.35 | 3.90E-06 | 4.95 E-03 | |
| GOTERM_MF_DIRECT | GO:0005887~integral component of plasma membrane | 39 | 12.68 | 4.80E-06 | 6.09 E-03 | |
| GOTERM_MF_DIRECT | GO:0031526~brush border membrane | 7 | 2.28 | 3.85E-05 | 0.05 | |
| GOTERM_MF_DIRECT | GO:0016324~apical plasma membrane | 13 | 4.23 | 2.91E-04 | 0.37 |