Table 3.
KEGG pathway analysis of differentially expressed genes associated with colorectal cancer.
| Category | Term | Count | % | P value | Genes | FRD |
|---|---|---|---|---|---|---|
| Upregulated | hsa04110: Cell cycle | 15 | 0.03 | 1.06E-06 | CDK1, DBF4, SKP2, CHEK1, PTTG1, MCM4, WEE1, YWHAG, CCND1, MAD2L1, MCM7, PLK1, PCNA, BUB1B, CCNA2 | 0.00133 |
| hsa04512: ECM-receptor interaction | 12 | 0.02 | 5.25E-06 | COL4A1, ITGAV, COMP, COL3A1, COL1A2, ITGA2, COL1A1, COL11A1, THBS2, COL5A2, COL5A1, SPP1 | 0.00658 | |
| hsa04510: Focal adhesion | 16 | 0.03 | 9.37E-05 | COL4A1, COL3A1, MET, ITGA2, COL5A2, COL5A1, CCND1, ITGAV, COMP, VEGFA, COL1A2, PDGFRB, COL1A1, THBS2, COL11A1, SPP1 | 0.11741 | |
| hsa04974: Protein digestion and absorption | 10 | 0.02 | 2.07E-04 | COL4A1, COL7A1, COL3A1, COL1A2, COL12A1, COL1A1, COL11A1, COL5A2, COL5A1, COL10A1 | 0.25962 | |
| hsa04151: PI3K-Akt signaling pathway | 19 | 0.03 | 1.19 E-03 | COL4A1, COL3A1, MET, ITGA2, COL5A2, COL5A1, DDIT4, YWHAG, EIF4EBP1, CCND1, ITGAV, COMP, VEGFA, COL1A2, PDGFRB, COL1A1, THBS2, COL11A1, SPP1 | 1.48049 | |
| Downregulated | hsa04978:Mineral absorption | 8 | 0.03 | 4.05E-06 | SLC26A3, TRPM6, CLCN2, MT1M, SLC9A3, MT1E, ATP1A2, MT1F | 0.00484 |
| hsa04964:Proximal tubule bicarbonate reclamation | 6 | 0.02 | 2.13E-05 | SLC9A3, CA4, ATP1A2, CA2, SLC4A4, PCK1 | 0.02546 | |
| hsa00830:Retinol metabolism | 7 | 0.02 | 4.22E-04 | ALDH1A1, UGT1A6, UGT2B17, ADH1C, DHRS9, ADH1B, UGT2B28 | 0.50270 | |
| hsa00040:Pentose and glucuronate interconversions | 5 | 0.02 | 1.55 E-03 | UGT1A6, UGT2B17, AKR1B10, UGDH, UGT2B28 | 1.82991 | |
| hsa00140:Steroid hormone biosynthesis | 6 | 0.02 | 1.89 E-03 | HSD3B2, UGT1A6, UGT2B17, HSD17B2, HSD11B2, UGT2B28 | 2.23810 |
KEGG, Kyoto Encyclopedia of Genes and Genomes; FDR, false discovery rate.