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. 2020 Feb 10;6(1):e001102. doi: 10.1136/rmdopen-2019-001102

Table 4.

Results of all-cause mortality following hospitalisation for pneumonia: a subanalysis of patients with rheumatoid arthritis (RA) and their preadmission treatments for RA with patients receiving methotrexate as a reference

RA therapy Mortality at 30 days n (%) HRs 30-day mortality Mortality at 90 days n (%) HRs 90-day mortality
N Crude Adjusted* Crude Adjusted*
All 1220 165 (13.5) 243 (19.9)
Methotrexate monotherapy 143 16 (11.2) 1.0 (ref) 1.0 (ref) 23 (16.1) 1.0 (ref) 1.0 (ref)
Any prednisolone† 526 71 (13.5) 1.23 (0.72 to 2.12) 1.16 (0.68 to 2.01) 121 (23.0) 1.48 (0.95 to 2.31) 1.43 (0.91 to 2.22)
Any biologics 46 1 (2.2) 0.19 (0.02 to 1.42) 0.35 (0.05 to 2.66) 1 (2.2) 0.13 (0.02 to 0.94) 0.21 (0.03 to 1.56)
Other csDMARDS as monotherapy 63 8 (12.7) 1.17 (0.50 to 2.73) 1.24 (0.53 to 2.92) 10 (15.9) 1.01 (0.48 to 2.12) 1.09 (0.52 to 2.29)
Combination therapy (csDMARDs) 48 1 (2.0) 0.18 (0.02 to 1.34) 0.27 (0.36 to 2.06) 3 (6.2) 0.37 (0.11 to 1.22) 0.56 (0.17 to 1.87)
No RA medication 394 68 (17.3) 1.60 (0.93 to 2.76) 1.49 (0.86 to 2.57) 85 (21.6) 1.40 (0.89 to 2.23) 1.35 (0.85 to 2.14)

Patients categorised according to therapy registered within 1 year prior to pneumonia admission.

Each patient was assigned to one group using the hierarchy described in the text and shown in online supplementary figure 1.

*Adjusted for sex, age, level of comorbidity, alcoholism, and antibiotic use before admission.

†Prescriptions for prednisolone 0–3 months prior to admission.

csDMARDs, conventional synthetic disease-modifying antirheumatic drugs.