Table 5.

Multivariate analyses of the relation between baseline characteristics and BMD over the study period*

	Women				Men
	Femoral neck		Lumbar spine		Femoral neck		Lumbar spine
	Mean difference	95% CI	Mean difference	95% CI	Mean difference	95% CI	Mean difference	95% CI
Postmenopausal	−0.50	−0.88 to −0.11	−0.33	−0.74 to 0.08	NA		NA
BMI	0.24	0.07 to 0.41	0.40	0.23 to 0.57	0.70	0.46 to 0.95	0.48	0.23 to 0.74
Smoking (ever)	−0.09	−0.44 to 0.26	−0.13	−0.49 to 0.23	0.38	−0.25 to 1.02	0.50	−0.16 to 1.17
Positive anti-CCP	NI		−0.39	−0.75 to −0.03	NI		NI
HRT	NI		0.67	0.23 to 1.11	NA		NA

Bold text indicates significant associations.

*Mixed linear effect models; estimated mean differences over time (Z-scores), per SD or positive versus negative. Adjusted for all variables in the table.

anti-CCP, anticyclic citrullinated protein; BMD, bone mineral density; BMI, body mass index; HRT, hormone replacement therapy; NA, not applicable; NI, not included.