Table 1. Basic features and characteristics of ferroptosis.

Morphological Feature	Biochemical Feature	Genetic Feature	Inducers	Inhibitors
Smaller mitochondria; increased membrane density; Reduced mitochondrial crista	Can not be modulated by compounds known to be inhibitors of regular cell death, such as caspase, cathepsin or calpain proteases (z-VAD-fmk, E64d or ALLN),RIPK1 (necrostatin-1), cyclophilin D (cyclosporin A	Required for erastin-induced ferroptosis: RPL8, IREB2, ATP5G3, CS,TTC35, ACSF2	Class 1 ferroptosis inducers: erastin, erastin derivatives (aldehyde erastin, morpholine erastin II, and piperazine erastin),buthionine sulfoximine, DPI2, glutamate, lanperisone, sulfasalazine, SRS13-45, SRS13-60); Class 2 ferroptosis inducers: DPI7, DPI10, DPI12, DPI13, DPI17, DPI18, DPI19, ML162, and RSL3; Drugs: Sorafenib and artemisinin derivatives (artesunate)	Antioxidants: Vitamin E, Trolox, U0126; inhibit ROS formation: Ferroptatin-1, SRS8-72, SRS11-92, SRS12-45, SRS13-35, SRS13-37, SRS16-86; Iron chelators: Desferoxamine, 2,2-bipyridy1, Ciclopirox olamine; Protein synthesis inhibitor: Cycloheximide) Transaminase inhibitor: Aminooxyacetie acid