Table 2.

Multiple logistic regression analysis of promoter single-nucleotide polymorphisms of IFI16 in schizophrenia patients and control subjects

SNP	Model	Genotype/allele	Con	SCZ	OR (95% CI)	p-value	Adjusted p-value
			N (%)	N (%)
rs1465175-760G/T	Additive	G/G	253 (61.6)	191 (68.5)	1
		G/T	139 (33.8)	85 (30.5)
		T/T	19 (4.6)	3 (1.1)	0.71 (0.53–0.95)	0.018	0.019
	Dominant	G/G	253 (61.6)	191 (68.5)	1
		G/T-T/T	158 (38.4)	88 (31.5)	0.75 (0.54–1.04)	0.083	0.093
	Recessive	G/G-G/T	392 (95.4)	276 (98.9)	1
		T/T	19 (4.6)	3 (1.1)	0.21 (0.06–0.75)	0.005	0.013
	Allele	G	670 (78.5)	467 (83.7)	1
		T	184 (21.5)	91 (16.3)	0.71 (0.54–0.94)	0.015	0.021
rs3754464-746A/G	Additive	A/A	279 (68.0)	162 (58.3)	1
		A/G	118 (28.8)	100 (36.0)
		G/G	13 (3.2)	16 (5.8)	1.41 (1.08–1.86)	0.013	0.019
	Dominant	A/A	279 (68.0)	162 (58.3)	1
		A/G-G/G	131 (32.0)	116 (41.7)	1.45 (1.05–2.00)	0.025	0.036
	Recessive	A/A-A/G	397 (96.8)	262 (94.2)	1
		G/G	13 (3.2)	16 (5.8)	1.95 (0.90–4.22)	0.082	0.082
	Allele	A	701 (82.3)	424 (76.7)	1
		G	151 (17.7)	132 (23.3)	1.45 (1.11–1.88)	0.006	0.019
rs1417806-491A/C	Additive	A/A	245 (59.6)	184 (66.0)	1
		C/A	140 (34.1)	89 (31.9)
		C/C	26 (6.3)	6 (2.1)	0.73 (0.55–0.96)	0.017	0.017
	Dominant	A/A	245 (59.6)	184 (66.0)	1
		C/A-C/C	166 (40.4)	95 (34.0)	0.76 (0.55–1.05)	0.083	0.083
	Recessive	A/A-C/A	385 (93.7)	273 (97.8)	1
		C/C	26 (6.3)	6 (2.1)	0.35 (0.14–0.87)	0.007	0.010
	Allele	A	654 (76.6)	457 (81.9)	1
		C	200 (23.4)	101 (18.1)	0.72 (0.55–0.94)	0.016	0.016

To counteract the problem of multiple comparison, p-values were adjusted using false discovery rate (FDR) test. Adjusted p-value means the p-value after adjustment for FDR test. A p-value lowering 0.05 was considered statistically significant. IFI16: IFN-γ-inducible protein 16, Con: control, SCZ: schizophrenia, OR: odds ratios, CI: confidence intervals, SNP: single nucleotide polymorphism