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. 2020 Feb 21;8:86. doi: 10.3389/fcell.2020.00086

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Copyright © 2020 Yu, Sun, An, Wen, Liu, Bu, Cui and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed pathway for sorting α-syn into exosomes. Exosomes participate in the secretion of α-syn in an endosome-dependent mechanism. First, α-syn is packaged into early endosomes. Next, α-syn containing exosomes can be secreted by two pathways. With the assistance of VPS4 and SUMO, it can be secreted as exosomal cargoes upon fusion of MVBs with the cytoplasmic membrane. Alternatively, α-syn containing exosomes can be sorted into recycling endosomes and be exocytosed as secretory granules in a Rab11a-dependent way.