Comparison 2. Patient‐reported outcomes.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 HAQ Disability Index	2	298	Mean Difference (IV, Fixed, 95% CI)	‐0.27 [‐0.39, ‐0.16]
1.1 12 weeks	1	28	Mean Difference (IV, Fixed, 95% CI)	‐0.14 [‐0.41, 0.13]
1.2 52 weeks	1	270	Mean Difference (IV, Fixed, 95% CI)	‐0.30 [‐0.42, ‐0.18]
2 Percent of improvement in HAQ‐Di	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 at least 20% Improvement	1	270	Risk Ratio (M‐H, Fixed, 95% CI)	1.84 [1.28, 2.63]
2.2 at least 50% Improvement	1	270	Risk Ratio (M‐H, Fixed, 95% CI)	2.18 [1.27, 3.73]
3 MHAQ	1	298	Mean Difference (IV, Fixed, 95% CI)	‐0.4 [‐0.52, ‐0.28]
4 Percent of improvement in MHAQ	1	596	Risk Ratio (M‐H, Fixed, 95% CI)	1.71 [1.35, 2.18]
4.1 >or= 20% Improvement	1	298	Risk Ratio (M‐H, Fixed, 95% CI)	1.52 [1.14, 2.02]
4.2 >or= 50% Improvement	1	298	Risk Ratio (M‐H, Fixed, 95% CI)	2.09 [1.36, 3.22]
5 Activities of Daily Living (ADL)	1	33	Mean Difference (IV, Random, 95% CI)	‐50.0 [‐67.81, ‐32.19]
6 Activities of Daily Living (ADL)	1	33	Risk Ratio (M‐H, Fixed, 95% CI)	10.39 [0.62, 173.97]
7 SF‐36 Physical component	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
7.1 >or= 20% Improvement	1	263	Risk Ratio (M‐H, Fixed, 95% CI)	1.45 [1.00, 2.12]
7.2 >or= 50% Improvement	1	263	Risk Ratio (M‐H, Fixed, 95% CI)	4.61 [1.88, 11.35]
8 SF‐36 Mental component	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
8.1 >or= 20% Improvement	1	263	Risk Ratio (M‐H, Fixed, 95% CI)	1.25 [0.79, 1.98]
8.2 >or= 50% Improvement	1	263	Risk Ratio (M‐H, Fixed, 95% CI)	1.71 [0.56, 5.24]
9 Pain	4	468	Mean Difference (IV, Fixed, 95% CI)	‐2.02 [‐2.41, ‐1.63]
9.1 12 weeks	1	27	Mean Difference (IV, Fixed, 95% CI)	‐1.70 [‐3.39, ‐0.01]
9.2 18 weeks	2	143	Mean Difference (IV, Fixed, 95% CI)	‐2.41 [‐3.19, ‐1.64]
9.3 52 weeks	1	298	Mean Difference (IV, Fixed, 95% CI)	‐1.90 [‐2.37, ‐1.43]
10 Pain	1	33	Risk Ratio (M‐H, Fixed, 95% CI)	5.65 [0.76, 41.89]
11 Patient global assessment	4	472	Std. Mean Difference (IV, Random, 95% CI)	‐1.15 [‐1.62, ‐0.68]
11.1 12 weeks	1	31	Std. Mean Difference (IV, Random, 95% CI)	‐1.74 [‐2.58, ‐0.89]
11.2 18 weeks	2	143	Std. Mean Difference (IV, Random, 95% CI)	‐1.25 [‐2.50, ‐0.01]
11.3 52 weeks	1	298	Std. Mean Difference (IV, Random, 95% CI)	‐0.88 [‐1.13, ‐0.64]
12 Improvement in PtGA	4	420	Risk Ratio (M‐H, Random, 95% CI)	2.47 [0.95, 6.46]
12.1 12 weeks	2	198	Risk Ratio (M‐H, Random, 95% CI)	3.87 [0.30, 49.72]
12.2 18 weeks	2	222	Risk Ratio (M‐H, Random, 95% CI)	2.50 [0.40, 15.62]
13 Morning stiffness	1	33	Risk Ratio (M‐H, Fixed, 95% CI)	2.82 [0.93, 8.60]
14 Morning stiffness	4	200	Mean Difference (IV, Random, 95% CI)	‐40.87 [‐95.96, 14.22]
14.1 12 weeks	2	57	Mean Difference (IV, Random, 95% CI)	‐27.03 [‐97.37, 43.30]
14.2 18 weeks	2	143	Mean Difference (IV, Random, 95% CI)	‐61.78 [‐168.59, 45.03]
15 Work Productivity	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
15.1 >or= 20% Improvement	1	240	Risk Ratio (M‐H, Fixed, 95% CI)	1.93 [1.22, 3.07]
15.2 >or= 50% Improvement	1	240	Risk Ratio (M‐H, Fixed, 95% CI)	2.35 [1.18, 4.67]