Table 1.

Study design to evaluate subretinal injection of AGTC-501 in RPGR mutant dogs

Group	No. of Animals	Dog ID and Sex	Dosage Level
			Vector Concentration (vg/mL)	Injection Volume (mL)	Total Dose (vg/eye)
Vehicle	3	Z559 F, Z569 M, Z587 M	0 (control)	0.07	0
Low dose	4	Z558 F, Z566 M, Z576 M, Z605 M	1.2 × 1011	0.07	8.4 × 109
Mid dose	4	Z555 M, Z574 M, Z594 M, Z603 M	6.0 × 1011	0.07	42 × 109
High dose	5	Z570 M, Z575 M, Z592 M, Z596 M, Z604 M	30 × 1011	0.07	210 × 109

Each animal received a subretinal injection in the right eye. The left eye was left untreated and used as control.

RPGR, retinitis pigmentosa GTPase regulator.