Skip to main content
. 2020 Feb 7;9(4):145–160. doi: 10.1089/wound.2019.0956

Figure 5.

Figure 5.

PI3K, EGFR, and ERK signaling pathways are important for the antimigratory function of hsa_circ_0084443 in keratinocytes. Gene expression profile of keratinocytes with hsa_circ_0084443 knockdown (n = 3) was analyzed by microarray. (A) Gene ontology analysis of the genes regulated by hsa_circ_0084443 (absolute fold change ≥1.5, p < 0.05). Live-cell imaging using the IncuCyte system of migrating keratinocytes with hsa_circ_0084443 knockdown (n = 6) and treated with DMSO or Wortmannin (1 μM) (B), PD153035 (500 nM) (C) or U0126 (10 μM) (D). The migration rates were calculated by measuring the area of the scratched region (B–D). *p < 0.05, ***p < 0.001, and ****p < 0.001 by two-way ANOVA. Data are presented as mean + SD. Color images are available online.