Table 5.
Insulin Use During the 96-h Hybrid Closed-Loop Period and the 7-Day Standard Therapy Period
| TDD of insulin | Adults |
Adolescents |
Children |
|||
|---|---|---|---|---|---|---|
| HCL | ST | HCL | ST | HCL | ST | |
| Overall, n | 11 | 10 | 15 | |||
| Units/day | 46 ± 16 | 54 ± 25 | 44 ± 12 | 60 ± 18 | 30 ± 11 | 32 ± 9 |
| Units/kg/day | 0.58 ± 0.19 | 0.67 ± 0.24 | 0.73 ± 0.18 | 1.01 ± 0.24 | 0.78 ± 0.19 | 0.84 ± 0.13 |
| Insulin dose based on prior insulin delivery modality | ||||||
| Prior pump users, n | 8 | 7 | 12 | |||
| Units/day | 44 ± 16 | 54 ± 28 | 49 ± 9 | 66 ± 17 | 30 ± 12 | 30 ± 9 |
| Units/kg/day | 0.53 ± 0.09 | 0.62 ± 0.17 | 0.82 ± 0.14 | 1.10 ± 0.21 | 0.82 ± 0.19 | 0.83 ± 0.13 |
| Prior MDI users, n | 3 | 3 | 3 | |||
| Units/day | 50 ± 19 | 56 ± 22 | 31 ± 10 | 45 ± 8 | 29 ± 6 | 39 ± 4 |
| Units/kg/day | 0.71 ± 0.33 | 0.80 ± 0.38 | 0.53 ± 0.06 | 0.79 ± 0.16 | 0.65 ± 0.05 | 0.88 ± 0.16 |
Data are mean ± SD unless otherwise indicated. HCL insulin dose is averaged over the entire 96-h HCL period.
TDD, total daily dose.