Figure 3.

Protein release of MSTCs compared with intact full-thickness skin. Six hundred sixty proteins were measured. Twenty-five proteins were increased significantly by more than twofold in MSTC-conditioned media, whereas 16 were significantly decreased by more than twofold. These proteins are grouped into four functional categories (membrane proteins, matrix remodeling, cytokines, and growth factors), and listed on the x-axes of their respective graphs in order of increasing concentration ratio between intact full-thickness skin versus skin column. The red dotted line on each graph marks the transition between factors that were more highly released from skin columns (on the left of each red line), versus those with reduced release from skin columns (on the right of each red line), compared with intact full-thickness skin. Color images are available online.