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. 2020 Feb 14;31(3-4):151–162. doi: 10.1089/hum.2019.274

Figure 1.

Figure 1.

Sequence and structures of AAV ITRs from serotypes 1–4, 6, and 7. (A) ITR2 with the RBE and RBE’ in bold. The terminal resolution nicking site TT dinucleotide is in red. (B) Consensus ITR sequence. Locations of nucleotide differences between ITR sequences 1–4, 6–7 are highlighted in red. The red nucleotides are in IUPAC code, where Y is C or T, R is A or G, S is G or C, W is A or T, K is G or T, M is A or C, B is G or T or C, V is G or C or A, and N is any nucleotide. Colored outlines denote the A (black), B (blue), C (gray), and D (green) regions in the ITR. (C) The sequence and structures of ITRs 1–4, 6–7. Bold letters denote non-conserved nucleotides between the ITR sequences. AAV, adeno-associated virus; RBE, Rep binding element; trs, terminal resolution site.