Table 2.
Consensus statements of EGb from the Asian Clinical Expert Group on Neurocognitive Disorders.
| No | Consensus statement | Concrete content |
|---|---|---|
| 1 | Efficacy of EGb 761® in AD, VaD, and BPSD | Best practice for the pharmacological treatment as follows: |
| AD: AChEI, memantine, EGb | ||
| VaD: AChEI, memantine, EGb, antiplatelet therapy | ||
| BPSD: ChEI, nonpharmacological treatment, antipsychotics (off-label), memantine, SSRIs, sedatives, and EGb | ||
| 2 | Management of MCI | EGb may be considered for use in patients with MCI |
| 3 | How to use EGb | EGb can be used as a single agent, and allow sufficient time to take effect |
| 4 | The dosage | EGb at daily dose of 240 mg |
| 5 | Lack of efficacy or intolerance of standard drugs may warrant use of EGb | EGb was recommended to treat AD, VaD, and mixed dementia, when the patients unable to tolerate the side effects of standard treatments |
| 6 | Adjunctive therapies | EGb was one of the key management options adjunctive to standard pharmacological therapy for AD, VaD, and BPSD |
| 7 | Management of comorbidities | EGb played an important role in the management of co-morbidities, such as hypertension, in patients with AD, VaD, and BPSD |
| 8 | Does not appear to prevent dementia | EGb was not recommended for prevention of dementia |
| 9 | Well tolerated | EGb had a good tolerability profile in the treatment of MCI, AD, VaD, and BPSD |
| 10 | No overall increased bleeding risk | EGb appeared to be no overall added risk of bleeding |
| 11 | No significant interaction with anticoagulants or antiplatelet agents | EGb had been demonstrated no significant interaction with anticoagulants and antiplatelet agents |
AD, Alzheimer’s disease; VaD, vascular dementia; BPSD, behavioral and psychological symptoms of dementia; MCI, mild cognitive impairment; AChEI, acetylcholinesterase inhibitors; SSRIs, Selective Serotonin Reuptake Inhibitors.