Table 3.
Univariate and multivariate COX proportional hazards regression analyses in training cohort.
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age | ||||||
| ≤ 69 | 1 | 1 | ||||
| >69 | 1.96 | (1.09, 3.52) | 0.024 | 2.58 | (1.40, 4.76) | 0.002 |
| Sex | ||||||
| Female | 1 | |||||
| Male | 1.75 | (0.97, 3.17) | 0.065 | |||
| T Stage | ||||||
| T1+T2 | 1 | |||||
| T3 | 2.29 | (0.69, 7.59) | 0.175 | |||
| T4 | 10.4 | (2.93, 36.93) | <0.001 | |||
| N Stage | ||||||
| N0 | 1 | |||||
| N1 | 2.84 | (1.38, 5.86) | 0.004 | |||
| N2 | 5.07 | (2.58, 9.98) | <0.001 | |||
| TNM Stage | ||||||
| I | 1 | 1 | ||||
| II | 1.22 | (0.34, 4.40) | 0.752 | 1.18 | (0.33, 4.25) | 0.803 |
| III | 2.89 | (0.83, 10.05) | 0.095 | 3.83 | (1.09, 13.45) | 0.036 |
| IV | 7.53 | (2.20, 25.81) | 0.001 | 8.22 | (2.37, 28.53) | 0.001 |
| Six-miRNA-based-signature | 1.74 | (1.44, 2.11) | <0.001 | 1.65 | (1.36, 1.99) | <0.001 |
HR, hazard ratio; CI, confidence interval.