Fig. 2.

Myeloid clusters in PBMC from HC, LTBI and TB. (a) tSNE of single cell profile with each cell color coded for myeloid subsets (left to right): the associated cell type, the corresponding status (HC, LTBI and TB) and merged all status. (b)The fraction of cells for myeloid subsets in HC, LTBI and TB. (c) Differential expression analysis was performed comparing myeloid subsets from HC, LTBI and TB. Heatmaps are shown representing the up- and down-regulated genes in Myeloid subsets. (d) Expression of marker genes for the myeloid subsets. (e) Differential expression analysis was performed comparing cells from HC, LTBI and TB within Myeloid cell subsets. (f) Differences in pathway activities scored per cell by GSVA between the different myeloid subsets.