Fig. 3.

B cell clusters in PBMC from HC, LTBI and TB. (a) tSNE of single cell profile with each cell color coded for B cell subsets (left to right): the associated cell type, the corresponding status (HC, LTBI and TB) and merged all status. (b)The fraction of cells for B cell subsets in HC, LTBI and TB. (c) Differential expression analysis was performed comparing B cell subsets from HC, LTBI and TB. Heatmaps are shown representing the up- and down-regulated genes in Myeloid subsets. (d) Expression of marker genes for the B cell subsets. (e) Differential expression analysis was performed comparing cells from HC, LTBI and TB within B cell subsets. (f) Differences in pathway activities scored per cell by GSVA between the different B clusters.