Table 3.
Prediction values of the rare genetic variants detected in the obesity cohort.
| Gene | Variant | Polyphen-2 | SIFT | CADD | MutationTaster |
|---|---|---|---|---|---|
| MC4R | V103Afs5* | Not applicable | Not applicable | Not applicable | Disease causing |
| MC4R | T112M | Possibly damaging | Tolerate | 8.9 | Polymorphism |
| ADCY3 | G1110R | Probably damaging | Deleterious | 34.0 | Disease causing |
| MYT1L | R807Q | Possibly damaging | Tolerate | 23.3 | Disease causing |
| ISL1 | I347F | Possibly damaging | Deleterious | 23.0 | Disease causing |
| LRP2 | R2479I | Probably damaging | Deleterious | 34.0 | Disease causing |
| LRP2 | N3315S | Probably damaging | Deleterious | 25.6 | Disease causing |
| GRPR | L87M | Probably damaging | Deleterious | 25.6 | Disease causing |