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. 2020 Feb 28;2020(2):CD012670. doi: 10.1002/14651858.CD012670.pub2
Source Search strategy Hits retrieved
ALOIS (CDCIG specialised register)
(http://www.medicine.ox.ac.uk/alois)
[Most recent search: 10 April 2019]		 adinazolam or alprazolam or bentazepam or benzodiazepine* or bromazepan or brotizolam or camazepam or chlordiazepoxide or clobazam or clotiazepam or cloxazolam or diazepam or etizolam or flunitrazepam or flurazepam or flutoprazepam or halazepam or ketazolam or loflazepate or loprazolam or lormetazepam or metaclazepam or midazolam or nitrazepam or oxzepam or prazepam or propazepam or ripazepam or serazepine or temazepan or tofisopam or triazolam Jun 2017: 42
Jun 2018: 0
Apr 2019: 0
CENTRAL (The Cochrane Library) http://crso.cochrane.org
[Most recent search: 10 April 2019]		 #1 MESH DESCRIPTOR delirium
#2 deliri*:TI,AB,KY
#3 ("acute confusion*"):TI,AB,KY
#4 ( "acute organic psychosyndrome"):TI,AB,KY
#5 ("acute brain syndrome"):TI,AB,KY
#6 ("metabolic encephalopathy"):TI,AB,KY
#7 ("acute psycho‐organic syndrome"):TI,AB,KY
#8 ("clouded state"):TI,AB,KY
#9 ("clouding of consciousness"):TI,AB,KY
#10 ("exogenous psychosis"):TI,AB,KY
#11 ("toxic psychosis"):TI,AB,KY
#12 ("toxic confusion"):TI,AB,KY
#13 obnubilat*:TI,AB,KY
#14 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13
#15 MESH DESCRIPTOR benzodiazepines EXPLODE ALL TREES
#16 MESH DESCRIPTOR anti‐anxiety agents
#17 adinazolam:TI,AB,KY
#18 alprazolam:TI,AB,KY
#19 bentazepam:TI,AB,KY
#20 benzodiazepine*:TI,AB,KY
#21 bromazepan:TI,AB,KY
#22 brotizolam:TI,AB,KY
#23 camazepam:TI,AB,KY
#24 chlordiazepoxide:TI,AB,KY
#25 clobazam:TI,AB,KY
#26 clotiazepam:TI,AB,KY
#27 cloxazolam:TI,AB,KY
#28 diazepam:TI,AB,KY
#29 etizolam:TI,AB,KY
#30 flunitrazepam:TI,AB,KY
#31 flurazepam:TI,AB,KY
#32 flutoprazepam:TI,AB,KY
#33 halazepam:TI,AB,KY
#34 ketazolam:TI,AB,KY
#35 loflazepate:TI,AB,KY
#36 loprazolam:TI,AB,KY
#37 lormetazepam:TI,AB,KY
#38 metaclazepam:TI,AB,KY
#39 midazolam:TI,AB,KY
#40 nitrazepam:TI,AB,KY
#41 oxzepam:TI,AB,KY 0
#42 prazepam:TI,AB,KY 73
#43 propazepam:TI,AB,KY
#44 ripazepam:TI,AB,KY
#45 serazepine:TI,AB,KY
#46 temazepan:TI,AB,KY
#47 tofisopam:TI,AB,KY
#48 triazolam:TI,AB,KY
#49 #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32 OR #33 OR #34 OR #35 OR #36 OR #37 OR #38 OR #39 OR #40 OR #41 OR #42 OR #43 OR #44 OR #45 OR #46 OR #47 OR #48
#50 #14 AND #49		 Jun 2017: 240
Jun 2018: 13
Apr 2019: 92
MEDLINE In‐process and other non‐indexed citations and MEDLINE 1950‐present (Ovid SP)
[Most recent search: 10 April 2019]		 1 exp benzodiazepines/
2 exp anti‐anxiety agents/
3 adinazolam.ti,ab.
4 alprazolam.ti,ab.
5 bentazepam.ti,ab.
6 benzodiazepine*.ti,ab.
7 bromazepan.ti,ab.
8 brotizolam.ti,ab.
9 camazepam.ti,ab.
10 chlordiazepoxide.ti,ab.
11 clobazam.ti,ab.
12 clotiazepam.ti,ab.
13 cloxazolam.ti,ab.
14 diazepam.ti,ab.
15 etizolam.ti,ab.
16 flunitrazepam.ti,ab.
17 flurazepam.ti,ab.
18 flutoprazepam.ti,ab.
19 halazepam.ti,ab.
20 ketazolam.ti,ab.
21 loflazepate.ti,ab.
22 loprazolam.ti,ab.
23 lormetazepam.ti,ab.
24 metaclazepam.ti,ab.
25 midazolam.ti,ab.
26 nitrazepam.ti,ab.
27 oxzepam.ti,ab.
28 prazepam.ti,ab.
29 propazepam.ti,ab.
30 ripazepam.ti,ab.
31 serazepine.ti,ab.
32 temazepan.ti,ab.
33 tofisopam.ti,ab.
34 triazolam.ti,ab.
35 or/1‐34
36 exp Delirium/
37 deliri*.ti,ab.
38 "acute confusion*".ti,ab.
39 "acute organic psychosyndrome".ti,ab.
40 "acute brain syndrome".ti,ab.
41 "metabolic encephalopathy".ti,ab.
42 "acute psycho‐organic syndrome".ti,ab.
43 "clouded state".ti,ab.
44 "clouding of consciousness".ti,ab.
45 "exogenous psychosis".ti,ab.
46 "toxic psychosis".ti,ab.
47 "toxic confusion".ti,ab.
48 obnubilat*.ti,ab.
49 or/36‐48
50 (randomized controlled trial or controlled clinical trial).pt.
51 randomized.ab.
52 placebo.ab.
53 drug therapy.fs.
54 randomly.ab.
55 trial.ab.
56 groups.ab.
57 or/50‐56
58 35 and 49 and 57
59 exp animals/ not humans.sh.
60 58 not 59		 Jun 2017: 816
Jun 2018: 54
Apr 2019: 57
Embase (Ovid SP)
1974 to 9 April 2019
[Most recent search: 10 April 2019]		 1 exp benzodiazepines/
2 exp anti‐anxiety agents/
3 adinazolam.ti,ab.
4 alprazolam.ti,ab.
5 bentazepam.ti,ab.
6 benzodiazepine*.ti,ab.
7 bromazepan.ti,ab.
8 brotizolam.ti,ab.
9 camazepam.ti,ab.
10 chlordiazepoxide.ti,ab.
11 clobazam.ti,ab.
12 clotiazepam.ti,ab.
13 cloxazolam.ti,ab.
14 diazepam.ti,ab.
15 etizolam.ti,ab.
16 flunitrazepam.ti,ab.
17 flurazepam.ti,ab.
18 flutoprazepam.ti,ab.
19 halazepam.ti,ab.
20 ketazolam.ti,ab.
21 loflazepate.ti,ab.
22 loprazolam.ti,ab.
23 lormetazepam.ti,ab.
24 metaclazepam.ti,ab.
25 midazolam.ti,ab.
26 nitrazepam.ti,ab.
27 oxzepam.ti,ab.
28 prazepam.ti,ab.
29 propazepam.ti,ab.
30 ripazepam.ti,ab.
31 serazepine.ti,ab.
32 temazepan.ti,ab.
33 tofisopam.ti,ab.
34 triazolam.ti,ab.
35 or/1‐34
36 exp Delirium/
37 deliri*.ti,ab.
38 "acute confusion*".ti,ab.
39 "acute organic psychosyndrome".ti,ab.
40 "acute brain syndrome".ti,ab.
41 "metabolic encephalopathy".ti,ab.
42 "acute psycho‐organic syndrome".ti,ab.
43 "clouded state".ti,ab.
44 "clouding of consciousness".ti,ab.
45 "exogenous psychosis".ti,ab.
46 "toxic psychosis".ti,ab.
47 "toxic confusion".ti,ab.
48 obnubilat*.ti,ab.
49 or/36‐48
50 randomized controlled trial/
51 controlled clinical trial/
52 random$.ti,ab.
53 randomization/
54 intermethod comparison/
55 placebo.ti,ab.
56 (compare or compared or comparison).ti.
57 ((evaluated or evaluate or evaluating or assessed or assess) and (compare or compared or comparing or comparison)).ab.
58 (open adj label).ti,ab.
59 ((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab.
60 double blind procedure/
61 parallel group$1.ti,ab.
62 (crossover or cross over).ti,ab.
63 ((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab.
64 (assigned or allocated).ti,ab.
65 (controlled adj7 (study or design or trial)).ti,ab.
66 (volunteer or volunteers).ti,ab.
67 trial.ti.
68 or/50‐67
69 35 and 49 and 68		 Jun 2017: 836
Jun 2018: 227
Apr 2019: 154
PsycINFO (Ovid SP)
[Most recent search: 10 April 2019]		 1. exp benzodiazepines/
2. adinazolam.ti,ab.
3. alprazolam.ti,ab.
4. bentazepam.ti,ab.
5. benzodiazepine*.ti,ab.
6. bromazepan.ti,ab.
7. brotizolam.ti,ab.
8. camazepam.ti,ab.
9. chlordiazepoxide.ti,ab.
10. clobazam.ti,ab.
11. clotiazepam.ti,ab.
12. cloxazolam.ti,ab.
13. diazepam.ti,ab.
14. etizolam.ti,ab.
15. flunitrazepam.ti,ab.
16. flurazepam.ti,ab.
17. flutoprazepam.ti,ab.
18. halazepam.ti,ab.
19. ketazolam.ti,ab.
20. loflazepate.ti,ab.
21. loprazolam.ti,ab.
22. lormetazepam.ti,ab.
23. metaclazepam.ti,ab.
24. midazolam.ti,ab.
25. nitrazepam.ti,ab.
26. oxzepam.ti,ab.
27. prazepam.ti,ab.
28. propazepam.ti,ab.
29. ripazepam.ti,ab.
30. Serazepine.ti,ab.
31. temazepan.ti,ab.
32. tofisopam.ti,ab.
33. triazolam.ti,ab.
34. or/1‐33
35. exp Delirium/
36. deliri*.ti,ab.
37. "acute confusion*".ti,ab.
38. "acute organic psychosyndrome".ti,ab.
39. "acute brain syndrome".ti,ab.
40. "metabolic encephalopathy".ti,ab.
41. "acute psycho‐organic syndrome".ti,ab.
42. "clouded state".ti,ab.
43. "clouding of consciousness".ti,ab.
44. "exogenous psychosis".ti,ab.
45. "toxic psychosis".ti,ab.
46. "toxic confusion".ti,ab.
47. obnubilat*.ti,ab.
48. or/35‐47
49. exp Clinical Trials/
50. randomly.ab.
51. randomi?ed.ti,ab.
52. placebo.ti,ab.
53. groups.ab.
54. "double‐blind*".ti,ab.
55. "single‐blind*".ti,ab.
56. RCT.ti,ab.
57. or/49‐56
58. 34 and 48 and 57		 Jun 2017: 37
Jun 2018: 70
Apr 2019: 1
CINAHL (EBSCOhost)
[Most recent search: 10 April 2019]		 1 (MH "antianxiety agents, benzodiazepine+")
2 TX adinazolam
3 TX alprazolam
4 TX bentazepam
5 TX benzodiazepine*
6 TX bromazepan
7 TX brotizolam
8 TX camazepam
9 TX chlordiazepoxide
10 TX clobazam
11 TX clotiazepam
12 TX cloxazolam
13 TX diazepam
14 TX etizolam
15 TX flunitrazepam
16 TX flurazepam
17 TX flutoprazepam
18 TX halazepam
19 TX ketazolam
20 TX loflazepate
21 TX loprazolam
22 TX lormetazepam
23 TX metaclazepam
24 TX midazolam
25 TX nitrazepam
26 TX oxzepam
27 TX prazepam
28 TX propazepam
29 TX ripazepam
30 TX serazepine
31 TX temazepan
32 TX tofisopam
33 TX triazolam
34 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S31 OR S32 OR S33
35 (MM "delirium")
36 TX deliri*
37 TX "acute confusion*"
38 TX "acute organic psychosyndrome"
39 TX "acute brain syndrome"
40 TX "metabolic encephalopathy"
41 TX "acute psycho‐organic syndrome"
42 TX "clouded state"
43 TX "clouding of consciousness"
44 TX "exogenous psychosis"
45 TX "toxic psychosis"
46 TX "toxic confusion"
47 TX obnubilat*
48 S35 OR S36 OR S37 OR S38 OR S39 OR S40 OR S41 OR S42 OR S43 OR S44 OR S45 OR S46 OR S47
49 MH "Clinical Trials"
50 TX trial
51 TX "single‐blind*"
52 TX "double‐blind*"
53 TX "treatment as usual"
54 TX randomly
55 S49 OR S50 OR S51 OR S52 OR S53 OR S54
56 S34 AND S48 AND S55		 Jun 2017: 158
Jun 2018: 16
Apr 2019: 21
ISI Web of Science ‐ all databases [includes: Web of Science (1945‐present); BIOSIS Previews (1926‐present); MEDLINE (1950‐present); Journal Citation Reports]
[Most recent search: 10 April 2019]		 (benzodiazepine* OR diazepam OR temazepan OR lorazepam OR alprazolam OR bromazepam OR nitrazepam OR clonazepam) AND TOPIC: (deliri* OR "acute confusion*" OR "acute organic psychosyndrome" OR "acute brain syndrome" OR "metabolic encephalopathy" OR "acute psycho‐organic syndrome" OR "clouded state" OR "clouding of consciousness" OR "exogenous psychosis" OR "toxic psychosis" OR "toxic confusion" OR obnubilat*) ANDTOPIC: (random* or placebo or "double‐blind" or trial OR groups OR "controlled study" OR "time series" OR "comparative study" OR "pretest‐posttest design") Jun 2017: 641
Jun 2018: 60
Apr 2019: 62
LILACS (BIREME)
[Most recent search: 10 April 2019]		 benzodiazepine* OR diazepam OR temazepan OR lorazepam OR alprazolam OR bromazepam OR nitrazepam OR clonazepam [Words] and and delirium OR delious OR deliria OR delirio OR loucura [Words] Jun 2017: 0
Jun 2018: 0
Apr 2019: 0
ClinicalTrials.gov
(www.clinicaltrials.gov)
[Most recent search: 10 April 2019]		 delirium OR toxic psychosis OR toxic confusion OR metabolic encephalopathy OR clouded state OR exogenous psychosis | benzodiazepine* OR diazepam OR temazepan OR lorazepam OR alprazolam OR bromazepam OR nitrazepam OR clonazepam Jun 2017: 15
Jun 2018: 1
Apr 2019: 6
ICTRP
(http://apps.who.int/trialsearch)
[Most recent search: 10 April 2019]		 delirium OR toxic psychosis OR toxic confusion OR metabolic encephalopathy OR clouded state OR exogenous psychosis | benzodiazepine* OR diazepam OR temazepan OR lorazepam OR alprazolam OR bromazepam OR nitrazepam OR clonazepam Jun 2017: 7
Jun 2018: 1
Apr 2019: 2
TOTAL before de‐duplication Jun 2017: 2792
Jun 2018: 442
Apr 2019: 415
TOTAL: 3649
TOTAL after de‐duplication Jun 2017: 2256
Jun 2018: 390
Apr 2019: 335
TOTAL: 2981
TOTAL after first assessment by information specialist Jun 2017: 466
Jun 2018: 61
Apr 2019: 95
TOTAL: 622