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. 2020 Feb 28;2020(2):CD001168. doi: 10.1002/14651858.CD001168.pub3

Bakhtiari 2017.

Methods Study design: RCT
Conducted in Iran
Number of centres: 1
Recruitment period: unclear
Funding source: unspecified
Participants Inclusion criteria: clinically and histopathologically diagnosed with reticular and erosive LP, seeking medical management
Exclusion criteria: presence of histological signs of dysplasia, use of drugs which caused lichenoid reactions, therapy for OLP in 2 months prior to the study, pregnant or breastfeeding women, uncontrolled systemic disease, lesions adjacent to amalgam fillings and people with photosensitivity
Group A: randomised 15; analysed 15
Group B: randomised 15; analysed 15
Interventions Group A: dexamethasone mouthwash (0.5 mg in 5 mL of water) 4 times daily + 1 nystatin mouthwash 4 times daily for 2 weeks
Group B: methylene blue as photosensitiser and light source of LED 630 nm (Fotosan, Denmark). Device was used according to manufacturer's instructions. Output power was 7.2–14.4 J/cm² and probe diameter was 8 mm. Participants gargled methylene blue 5% for 5 minutes and 10 minutes prior to irradiation. Each lesion was irradiated for 30 seconds up to 2 minutes with spot technique
Outcomes Pain (VAS), clinical score (Thongprasom), clinical severity index, EI
Measured at days 15, 30, 60 and 90 after beginning of the treatment
Notes VAS results were reported graphically; data extraction was not possible
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Comment: insufficient information to permit judgement.
Allocation concealment (selection bias) Unclear risk Comment: insufficient information to permit judgement.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Comment: blinding not feasible.
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Comment: participants (self‐assessed, pain was primary outcome) were not blinded.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Comment: no missing data. All randomised participants included in analysis.
Selective reporting (reporting bias) High risk Comment: ≥ 1 outcomes of interest were reported incompletely (standard deviations were missing) so data could not be entered in a meta‐analysis.
Other bias Low risk No other sources of bias identified.