Laeijendecker 2006.

Methods	Study design: RCT Conducted in Netherlands Number of centres: 1 Recruitment period: 2001–2004 Funding source: unspecified
Participants	Inclusion criteria: Caucasian people with a confirmed diagnosis of symptomatic OLP based on clinical and histopathological features Exclusion criteria: aged < 18 years; histopathological examination with atypical or lichenoid dysplastic features; asymptomatic oral lesions and specific treatment within 4 weeks prior to the study Group A: randomised 20; analysed 20 Group B: randomised 20; analysed 20
Interventions	Group A: tacrolimus 0.1% ointment, 4 times daily for 6 weeks Group B: triamcinolone acetonide 0.1% in hypromellose 20% ointment, 4 times daily for 6 weeks
Outcomes	Clinical score (4‐grade score), adverse effects
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "pre‐determined randomisation list stratified by sex."
Allocation concealment (selection bias)	Unclear risk	Comment: insufficient information to permit judgement.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Comment: insufficient information to permit judgement.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Comment: insufficient information to permit judgement.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Comment: no missing data. All randomised participants included in analysis.
Selective reporting (reporting bias)	Low risk	Planned outcomes reported.
Other bias	Low risk	No other sources of bias identified.